Thermo Fisher Scientific TSLP Polyclonal Antibody
TSLP 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot 및 Immunohistochemistry에 적합하며 Mouse, Rat 시료 반응. 항원 친화 크로마토그래피로 정제된 고순도 항체로, 연구용으로만 사용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 0.5–2 µg/mL | View 1 publication |
| Immunohistochemistry (IHC) | – | View 2 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | 2.5 µg/mL | View publication |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 20 µg/mL | View publication |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Mouse, Rat |
| Published Species | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A 20 amino acid peptide from near the center of mouse TSLP |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long-term storage, store at –20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11156395 |
Product Specific Information
Despite its predicted molecular weight, TSLP often migrates at a higher molecular weight in SDS-PAGE.
A suggested positive control is A-20 cell lysate.
PA5-20321 can be used with blocking peptide PEP-0441.
Target Information
TSLP is a 159 amino acid four-helix bundle hemopoietic cytokine that signals through a heterodimeric receptor complex consisting of the human TSLP receptor and the IL-7R alpha-chain.
It impacts myeloid cells and induces the release of T cell-attracting chemokines from monocytes, enhances the maturation of CD11c(+) dendritic cells, naive CD4(+) and CD8(+) T cells into proallergic effectors, and primes dendritic cells to produce large amounts of IL-12 after CD40 ligand stimulation.
TSLP influences the regulation of the positive selection of regulatory T cells and maintenance of peripheral CD4(+) T cell homeostasis.
It induces allergic inflammation by directly activating mast cells and may be involved in the pathophysiology of inflammatory arthritis.
It is expressed in heart, liver, and prostate.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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