Thermo Fisher Scientific Protein Z Monoclonal Antibody (OTI4D5)
인간 단백질 Z를 인식하는 Mouse monoclonal antibody (Clone OTI4D5). IHC(P)에서 1:150로 사용 가능. 비결합형 액상 항체로, PBS 기반 버퍼에 1% BSA 및 50% glycerol 포함. -20°C 보관, 동결/해동 반복 피해야 함. 연구용 전용.
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Applications and Tested Dilution
- Immunohistochemistry (Paraffin) (IHC (P)): 1:150
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI4D5 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 115–400 of PROZ produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2725116 |
Target Information
PROZ (Protein Z) is a vitamin K-dependent plasma glycoprotein of approximately 62 kDa and 396 amino acids. It contains four domains: a Gla-rich region, two EGF-like domains, and a trypsin-like domain.
Although structurally related to serine proteases (factors VII, IX, X, and protein C), Protein Z lacks catalytic activity due to the absence of a critical serine residue.
It participates in the coagulation cascade by facilitating the degradation of factor Xa through the protein Z–related protease inhibitor (ZPI), with its activity enhanced 1000-fold in the presence of Protein Z.
Deficiency in Protein Z has been variably associated with both thrombosis and bleeding tendencies.
For Research Use Only.
Not for use in diagnostic procedures or resale without express authorization.
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