Thermo Fisher Scientific KLHL12 Monoclonal Antibody (OTI4C10), TrueMAB
인간 KLHL12 단백질을 인식하는 마우스 단클론 항체입니다. Western blot에 적합하며, CUL3 기반 유비퀴틴 E3 리가아제 복합체 연구에 활용됩니다. 동결건조 형태로 제공되며, 재구성 후 약 1 mg/mL 농도로 사용 가능합니다. 연구용 전용 제품입니다.
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Applications
- Western Blot (WB): Tested dilution 1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI4C10 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 177–405 of human KLHL12 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, avoid freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL of distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step (recommended: Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
KLHL12 functions as a substrate-specific adapter for the CUL3-based ubiquitin-protein E3 ligase complex. It negatively regulates the Wnt signaling pathway through targeted ubiquitination and proteolysis of DVL3.
Tissue specificity: Highly expressed in testis and at lower levels in the submandibular salivary gland.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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