Thermo Fisher Scientific Caspase 5 Polyclonal Antibody
Human Caspase 5를 인식하는 Rabbit Polyclonal Antibody로, IHC(P)에서 1:20–1:50 희석 비율로 사용 가능. 항원 친화 크로마토그래피로 정제된 액상 형태이며, PBS/glycerol buffer에 보관. 염증성 caspase 연구 및 면역반응 분석에 적합.
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Applications
- Immunohistochemistry (Paraffin) (IHC (P)): Tested dilution 1:20–1:50
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Protein corresponding to Human Caspase 5. Recombinant protein control fragment (Product #RP-98453) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.05 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term; for long term, store at -20°C (avoid freeze/thaw cycles) |
| Shipping Conditions | Wet ice |
| RRID | AB_2856536 |
Product Specific Information
Immunogen sequence:
VEGVFIFLIE DSGKKKRRKN FEAMFKGILQ SGLDNFVINH MLKNNVAGQT SIQTLVPNTD QKSTSVKKDN HKKKTVKMLE YLGKDV
Target Information
Caspases are a family of cysteine proteases divided into apoptotic and inflammatory subfamilies. The inflammatory caspases (including caspase-1, -4, -5, and -12) are associated with immune responses rather than cell death. Activation of these caspases leads to cleavage and activation of proinflammatory cytokines such as IL-1β and IL-18.
Caspase-5 interacts with caspase-1 as part of the NALP1 inflammasome, triggering cleavage of pro-IL-1β. Expression of caspase-5 can be regulated by LPS and IFN-γ.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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