Thermo Fisher Scientific NEK8 Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:50

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant Protein corresonding to Human NEK8. Recombinant protein control fragment (Product #RP-98306). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:NEK8,uniProtId:Q86SG6-1,ncbiNodeId:9606,antigenRange:375-449,antigenLength:692,antigenImageFileName:PA5-111124_NEK8_Q86SG6-1_Rabbit.svg,antigenImageFileNamePDP:PA5-111124_NEK8_Q86SG6-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2856534

Product Specific Information

Immunogen sequence: QPQPQFISRF LEGQSGVTIK HVACGDFFTA CLTDRGIIMT FGSGSNGCLG HGSLTDISQP TIVEALLGYE MVQVA

Target Information

NEK8 serine/threonine kinase or NIMA-related kinase 8 is related to NIMA (never in mitosis, gene A) of Aspergillus nodulins and may play a role in cell cycle progression from G2 to M phase. NEK8 is part of a complex of ciliary proteins required for renal and cardiovascular development. NEK8 interacts with polycystin signal transduction pathways and may control the targeting of these ciliary proteins. Required for renal tubular integrity. May regulate local cytoskeletal structure in kidney tubule epithelial cells. May regulate ciliary biogenesis through targeting of proteins to the cilia.Defects in NEK8 are the cause of nephronophthisis type 9 (NPHP9) [MIM:613824]. NPHP9 is an autosomal recessive disorder resulting in end-stage renal disease. It is a progressive tubulo-interstitial kidney disorder histologically characterized by modifications of the tubules with thickening of the basement membrane, interstitial fibrosis and, in the advanced stages, medullary cysts.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.