Thermo Fisher Scientific SOCS3 Polyclonal Antibody
Human, Mouse, Rat 반응성을 가진 SOCS3 폴리클로날 항체로, IHC, ICC/IF, ELISA 등 다양한 응용에 적합. KLH 결합 합성 펩타이드(aa 155-225)를 면역원으로 사용. 단백질 A 정제, 액상 형태, -20°C 보관.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1:5,000–1:10,000 |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human Socs 3, amino acids 155–225 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Cytokine receptor signaling is negatively regulated by a family of Src homology 2 domain-containing adaptor molecules termed SOCS (Suppressor of Cytokine Signaling). Eight members of the SOCS family have been identified: SOCS-1, 2, 3, 4, 5, 6, 7, and CIS. Structurally, SOCS proteins consist of an N-terminal variable region, a central SH2 domain, and a C-terminal SOCS box motif. These proteins form a classical negative feedback loop that regulates cytokine signal transduction via a STAT-induced transcriptional mechanism. SOCS genes are rapidly transcribed in response to cytokines and inhibit signaling through various mechanisms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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