Thermo Fisher Scientific Collagen 1 Polyclonal Antibody
Collagen I 단백질을 인식하는 Rabbit Polyclonal Antibody로 다양한 종에 반응합니다. Western blot, IHC, ICC, Flow cytometry, ELISA 등에 사용 가능하며, 고순도의 Protein A 정제 및 안정적인 액상 형태로 제공됩니다. 연구용으로만 사용됩니다.
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Thermo Fisher Scientific Collagen 1 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:300 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:300 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| Flow Cytometry (Flow) | 1:20–1:100 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Item | Description |
|---|---|
| Species Reactivity | Dog, Fish, Human, Mouse, Rabbit, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human Collagen I C-terminal propeptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Collagen I is a Type I collagen with a triple helix structure comprised of two alpha-1 chains and one alpha-2 chain. It is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis, and tendon.
Mutations in the COL1A2 gene encoding the alpha-2 chain are associated with osteogenesis imperfecta types I–IV, Ehlers-Danlos syndrome type VIIB, recessive Ehlers-Danlos Classical type, idiopathic osteoporosis, and atypical Marfan syndrome.
Symptoms linked to COL1A2 mutations tend to be less severe than those in COL1A1, reflecting the distinct roles of alpha-2 chains in matrix integrity.
Reciprocal translocations between chromosomes 17 and 22, where Collagen Type I genes and the gene for platelet-derived growth factor beta are located, are associated with dermatofibrosarcoma protuberans. This tumor arises from unregulated expression of the growth factor.
Two transcripts from alternate polyadenylation signals have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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