Thermo Fisher Scientific CD8 alpha Monoclonal Antibody (YTS169.4), FITC
FITC 형광 표지된 CD8 alpha 단클론 항체로 마우스 시료에 반응합니다. Flow Cytometry에 적합하며, 단클론 Rat IgG2b 형식입니다. Protein G 정제, PBS/BSA 버퍼에 보관하며 4°C 단기, -20°C 장기 저장 가능합니다.
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Applications
Flow Cytometry (Flow)
- Tested Dilution: 1 µg/1x10^6 cells
- View 2 publications
Miscellaneous PubMed (Misc)
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Published Species | Mouse |
| Host / Isotype | Rat / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | YTS169.4 |
| Immunogen | Mouse Ly-2 thymocytes |
| Conjugate | FITC |
| Excitation / Emission Max | 498 / 517 nm |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS with 4–5 mg/mL BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term; -20°C long term (avoid freeze/thaw cycles). Store in the dark. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2538994 |
Additional Formats
Target Information
Cluster of differentiation 8 (CD8) is a type I transmembrane glycoprotein of the immunoglobulin family that plays an integral role in signal transduction and T cell differentiation and activation.
CD8 is predominantly expressed on T cells as a disulfide-linked heterodimer of CD8α and CD8β, functioning as a co-receptor with the T cell receptor (TCR) for MHC-I molecules.
CD8α can also form homodimers on subsets of T cells, NK cells, monocytes, and dendritic cells.
Binding of MHC-I/peptide complexes by CD8 triggers recruitment of Lck kinase, leading to cytokine production, motility, and cytotoxic T lymphocyte (CTL) activation.
Activated CTLs are crucial for pathogen and tumor cell clearance. Differentiation of naive CD8+ T cells into CTLs is enhanced by IL-2, IL-12, and TGF-β1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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