Thermo Fisher Scientific VAMP1/VAMP2 Monoclonal Antibody (SP10)

Applications

Tested Dilution

Publications

Western Blot (WB)

Assay-dependent

-

Flow Cytometry (Flow)

Assay-dependent

-

ELISA (ELISA)

Assay-dependent

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgM

Class

Monoclonal

Type

Antibody

Clone

SP10

Immunogen

Human Synaptobrevin 1 (aa 1-118) and Synaptobrevin 2(aa 33-96). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:VAMP1/VAMP2,uniProtId:P63027-1,ncbiNodeId:9606,antigenRange:33-96,antigenLength:116,antigenImageFileName:MA5-17608_VAMP1VAMP2_P63027-1_House_mouse.svg,antigenImageFileNamePDP:MA5-17608_VAMP1VAMP2_P63027-1_House_mouse_PDP.jpeg,sortOrder:1},{targetFamily:VAMP1/VAMP2,uniProtId:P23763-1,ncbiNodeId:9606,antigenRange:1-118,antigenLength:118,antigenImageFileName:MA5-17608_VAMP1VAMP2_P23763-1_House_mouse.svg,antigenImageFileNamePDP:MA5-17608_VAMP1VAMP2_P23763-1_House_mouse_PDP.jpeg,sortOrder:2}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2538998

Product Specific Information

MA5-17608 targets VAMP/synaptobrevin in ELISA, FACS, and WB applications and shows reactivity with Human samples.

The MA5-17608 immunogen is human Synaptobrevin 1 (aa 1-118) and Synaptobrevin 2(aa 33-96).

Target Information

Vesicle-associated membrane protein 2 is essential for cAMP-regulated exocytosis. VAMP (also know as synaptobrevin) is part of the synaptic vesicle docking and fusion complex and plays a central role in neuroexocytosis. Two VAMP (vesicle-associated membrane protein) isoforms are expressed in the nervous system and are differently distributed among the specialized parts of the tissue. VAMP-1 and -2 are present in all tissues tested, including kidney, adrenal gland, liver, pancreas, thyroid, heart, and smooth muscle. The two isoforms are differentially expressed in various tissues and their level may depend on differentiation. VAMP-1 is restricted to exocrine pancreas and to kidney tubular cells, whereas VAMP-2 is the predominant isoform present in Langerhans islets and in glomerular cells. Both isoforms show a patchy vesicular intracellular distribution in confocal microscopy. Evidence for the importance of neuronal VAMPproteins in the physiology of all cells is indicated.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.