Thermo Fisher Scientific JARID1C Polyclonal Antibody
인간 JARID1C 단백질을 인식하는 Rabbit Polyclonal 항체. 면역세포화학(ICC/IF)에 적합하며 0.25–2 µg/mL 농도로 사용. 항원 친화 크로마토그래피로 정제됨. PBS, 40% 글리세롤 완충액에 보관하며 4°C 단기, -20°C 장기 저장 권장.
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Applications
- Immunocytochemistry (ICC/IF)
Tested dilution: 0.25–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human KDM5C. Recombinant protein control fragment (Product # RP-106111) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2790959 |
Product Specific Information
Immunogen sequence:
LGLMAKDKTL RKKDKEGPEC PPTVVVKEEL GGDVKVESTS PKTFLESKEE LSHSPEPCTK MTMRLRRNHS NAQFIESYVC RMCSRG
Target Information
Serine/threonine kinase which acts as a negative regulator of Ras-related Rap2-mediated signal transduction to control neuronal structure and AMPA receptor trafficking. Required for normal synaptic density, dendrite complexity, as well as surface AMPA receptor expression in hippocampal neurons. Can activate the JNK and MAPK14/p38 pathways and mediates stimulation of the stress-activated protein kinase MAPK14/p38 MAPK downstream of the Raf/ERK pathway. Phosphorylates: TANC1 upon stimulation by RAP2A, MBP and SMAD1. Has an essential function in negative selection of thymocytes, perhaps by coupling NCK1 to activation of JNK1. Isoform 4 can activate the JNK pathway. Involved in the regulation of actin cytoskeleton reorganization, cell-matrix adhesion, cell-cell adhesion and cell migration.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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