Thermo Fisher Scientific CD1a Monoclonal Antibody (HI149), APC

Applications

• Flow Cytometry (Flow)
  Tested Dilution: 10 µL / 1×10⁶ cells

Product Specifications

Additional Formats

• Unconjugated: MA1-19314
• FITC: MA1-19605
• PE: MA1-10130
• Custom conjugation available upon request

Product Specific Information

This antibody reacts with an extracellular epitope of CD1a (T6), a 49 kDa polypeptide associated with beta2-microglobulin expressed on cortical thymocytes (strongly), Langerhans cells, dendritic cells, and some T-cell leukemias and lymphomas.
It does not react with peripheral blood T and B lymphocytes, monocytes, granulocytes, platelets, or erythrocytes.

Target Information

CD1a is a non-polymorphic MHC Class I-related cell surface glycoprotein expressed in association with beta-2 microglobulin. It is found on cortical thymocytes, Langerhans cells, dendritic cells, certain T-cell leukemias, and other tissues.
CD1a mediates presentation of lipid and glycolipid antigens to T cells. The CD1 family (CD1a–e) genes are clustered on chromosome 1 and differ in localization and ligand specificity. CD1a localizes to the plasma membrane and early endocytic vesicles.
Alternatively spliced variants have been observed, though their biological significance remains unclear.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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