
Thermo Fisher Scientific CD1a Monoclonal Antibody (HI149), APC
인간 CD1a 항원에 특이적인 마우스 모노클로날 항체로 APC 형광체가 결합되어 있습니다. Flow Cytometry에 적합하며, Langerhans 세포 및 T 세포 관련 종양 연구에 활용됩니다. 고순도 크로마토그래피로 정제되어 안정적인 신호를 제공합니다.
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Applications
- Flow Cytometry (Flow)
Tested Dilution: 10 µL / 1×10⁶ cells
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | HI149 |
| Immunogen | Human thymocytes |
| Conjugate | APC |
| Excitation / Emission Max | 651 / 660 nm |
| Form | Liquid |
| Purification | Size-exclusion chromatography |
| Storage Buffer | PBS, pH 7.4, with 0.2% BSA |
| Contains | 15 mM sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2534493 |
Additional Formats
- Unconjugated: MA1-19314
- FITC: MA1-19605
- PE: MA1-10130
- Custom conjugation available upon request
Product Specific Information
This antibody reacts with an extracellular epitope of CD1a (T6), a 49 kDa polypeptide associated with beta2-microglobulin expressed on cortical thymocytes (strongly), Langerhans cells, dendritic cells, and some T-cell leukemias and lymphomas.
It does not react with peripheral blood T and B lymphocytes, monocytes, granulocytes, platelets, or erythrocytes.
Target Information
CD1a is a non-polymorphic MHC Class I-related cell surface glycoprotein expressed in association with beta-2 microglobulin. It is found on cortical thymocytes, Langerhans cells, dendritic cells, certain T-cell leukemias, and other tissues.
CD1a mediates presentation of lipid and glycolipid antigens to T cells. The CD1 family (CD1a–e) genes are clustered on chromosome 1 and differ in localization and ligand specificity. CD1a localizes to the plasma membrane and early endocytic vesicles.
Alternatively spliced variants have been observed, though their biological significance remains unclear.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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