Thermo Fisher Scientific LDLR Polyclonal Antibody
LDLR 단백질을 인식하는 Rabbit Polyclonal 항체로 Western blot 및 Immunoprecipitation에 적합합니다. 인간에 반응하며, 마우스·랫·소·토끼에도 예측 반응합니다. 항원 친화 크로마토그래피로 정제되었으며, 4°C 보관이 권장됩니다.
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Applications
Western Blot (WB)
- Assay-dependent
Immunoprecipitation (IP)
- 2–10 µg/mg lysate
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 810 to 860 of human Low Density Lipoprotein Receptor |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | Tris citrate/phosphate, pH 7–8 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Based on 100% sequence identity, this antibody is predicted to react with Mouse, Rat, Bovine, and Rabbit
Target Information
The low density lipoprotein receptor (LDL-R) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) binds to the cell membrane and is internalized into lysosomes, where the protein is degraded and cholesterol becomes available for repression of the microsomal enzyme HMG CoA reductase, the rate-limiting step in cholesterol synthesis. Concurrently, cholesterol ester synthesis is stimulated. Mutations in the LDL-R gene cause familial hypercholesterolemia, an autosomal dominant disorder. Along with SCARB1, CLDN1, and CD81, LDL-R has been reported to act as an entry factor for the Hepatitis C virus. At least three isoforms of LDL-R are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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