Thermo Fisher Scientific LDLR Polyclonal Antibody

Applications

Western Blot (WB)

• Assay-dependent

Immunoprecipitation (IP)

• 2–10 µg/mg lysate

Product Specifications

Product Specific Information

• Recommended shelf life: 1 year from date of receipt
• Based on 100% sequence identity, this antibody is predicted to react with Mouse, Rat, Bovine, and Rabbit

Target Information

The low density lipoprotein receptor (LDL-R) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) binds to the cell membrane and is internalized into lysosomes, where the protein is degraded and cholesterol becomes available for repression of the microsomal enzyme HMG CoA reductase, the rate-limiting step in cholesterol synthesis. Concurrently, cholesterol ester synthesis is stimulated. Mutations in the LDL-R gene cause familial hypercholesterolemia, an autosomal dominant disorder. Along with SCARB1, CLDN1, and CD81, LDL-R has been reported to act as an entry factor for the Hepatitis C virus. At least three isoforms of LDL-R are known to exist.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.