Thermo Fisher Scientific APC5 Polyclonal Antibody

Applications

Product Specifications

Product Specific Information

Immunogen sequence:
LSQQASLLKN DETKALTPAS LQKELNNLLK FNPDFAEAHY LSYLNNLRVQ DVFSSTHSLL HYFDRLILTG AESKSNGEEG YGRSLR

Target Information

This gene encodes a tetratricopeptide repeat-containing component of the anaphase promoting complex/cyclosome (APC/C), a large E3 ubiquitin ligase that controls cell cycle progression by targeting cell cycle regulators such as B-type cyclins for 26S proteasome-mediated degradation through ubiquitination.
The encoded protein is required for proper ubiquitination function of APC/C and for interaction with transcription coactivators. It also interacts with polyA binding protein and represses internal ribosome entry site-mediated translation.
Multiple transcript variants encoding different isoforms have been found for this gene. These differences cause translation initiation at a downstream AUG and result in a shorter protein compared to isoform a.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.