Thermo Fisher Scientific APC5 Polyclonal Antibody
APC5 단백질을 인식하는 Rabbit Polyclonal Antibody로, Western blot 및 IHC(P) 실험에 적합합니다. Human, Mouse, Rat 반응성이 있으며, 항원 친화 크로마토그래피로 정제되었습니다. 세포 주기 조절 관련 연구에 유용합니다.
- 카탈로그번호
- PA583464
- 판매단위
- pk
카탈로그
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human ANAPC5. Recombinant protein control fragment (Product #RP-97657). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.3 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2790619 |
Product Specific Information
Immunogen sequence:
LSQQASLLKN DETKALTPAS LQKELNNLLK FNPDFAEAHY LSYLNNLRVQ DVFSSTHSLL HYFDRLILTG AESKSNGEEG YGRSLR
Target Information
This gene encodes a tetratricopeptide repeat-containing component of the anaphase promoting complex/cyclosome (APC/C), a large E3 ubiquitin ligase that controls cell cycle progression by targeting cell cycle regulators such as B-type cyclins for 26S proteasome-mediated degradation through ubiquitination.
The encoded protein is required for proper ubiquitination function of APC/C and for interaction with transcription coactivators. It also interacts with polyA binding protein and represses internal ribosome entry site-mediated translation.
Multiple transcript variants encoding different isoforms have been found for this gene. These differences cause translation initiation at a downstream AUG and result in a shorter protein compared to isoform a.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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