Thermo Fisher Scientific AXIN2 Recombinant Rabbit Monoclonal Antibody (23GB1545)
AXIN2 단백질을 표적으로 하는 Thermo Fisher Scientific의 재조합 토끼 단클론 항체. Western blot과 ICC/IF에 적합하며, 인간, 생쥐, 랫트에 반응. HEK293F 발현 시스템 기반으로 높은 특이성과 재현성을 제공. 연구용으로만 사용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:5,000 |
| Immunocytochemistry (ICC/IF) | 1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293F |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 23GB1545 |
| Immunogen | A synthesized peptide derived from human Axin2 (58–93AA) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice (domestic); Dry ice (international) |
Target Information
The Axin-related protein, Axin2, plays an important role in regulating the stability of beta-catenin in the Wnt signaling pathway. In mouse, conductin (Axin2 homolog) organizes a multiprotein complex including APC, beta-catenin, and glycogen synthase kinase 3-beta, leading to beta-catenin degradation. Deregulation of beta-catenin is associated with various malignancies. The AXIN2 gene is mapped to 17q23–q24, a region showing frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene are linked to colorectal cancer with defective mismatch repair.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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