Thermo Fisher Scientific Synaptotagmin 3 Polyclonal Antibody
Rabbit polyclonal antibody targeting human Synaptotagmin 3 (SYT3). Validated for IHC (Paraffin) at 1:50–1:100 dilution. Detects endogenous SYT3 protein involved in calcium-dependent exocytosis. Purified by antigen affinity chromatography, supplie...
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Applications
- Immunohistochemistry (Paraffin) (IHC (P)): 1:50–1:100 dilution
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Fusion protein corresponding to a region derived from internal residues of human synaptotagmin III |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.9 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 40% glycerol |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2635721 |
Product Specific Information
The antibody detects endogenous levels of total SYT3 protein.
Target Information
Synaptotagmins are a large gene family of synaptic vesicle type III integral membrane proteins that regulate both exocytosis and endocytosis, playing a key role in neurotransmitter secretion.
- Synaptotagmin I: Calcium binding triggers neurotransmitter release at synapses.
- Synaptotagmin II: Phosphorylated by WNK1, regulating calcium-dependent interactions.
- Synaptotagmin III: Involved in calcium-dependent exocytosis of secretory vesicles in endocrine cells and neurons.
- Synaptotagmin IV: Highly expressed in neuronal tissues, especially the hippocampus; potentially linked to psychiatric disorders.
- Synaptotagmin V: Dense-core vesicle-specific protein regulating calcium-regulated secretion.
- Synaptotagmin VI: Interacts with adaptor protein-2 in a calcium-independent manner.
- Synaptotagmin VII: Widely expressed in non-neuronal tissues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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