Thermo Fisher Scientific Synaptotagmin 3 Polyclonal Antibody

Applications

• Immunohistochemistry (Paraffin) (IHC (P)): 1:50–1:100 dilution

Product Specifications

Product Specific Information

The antibody detects endogenous levels of total SYT3 protein.

Target Information

Synaptotagmins are a large gene family of synaptic vesicle type III integral membrane proteins that regulate both exocytosis and endocytosis, playing a key role in neurotransmitter secretion.

• Synaptotagmin I: Calcium binding triggers neurotransmitter release at synapses.
• Synaptotagmin II: Phosphorylated by WNK1, regulating calcium-dependent interactions.
• Synaptotagmin III: Involved in calcium-dependent exocytosis of secretory vesicles in endocrine cells and neurons.
• Synaptotagmin IV: Highly expressed in neuronal tissues, especially the hippocampus; potentially linked to psychiatric disorders.
• Synaptotagmin V: Dense-core vesicle-specific protein regulating calcium-regulated secretion.
• Synaptotagmin VI: Interacts with adaptor protein-2 in a calcium-independent manner.
• Synaptotagmin VII: Widely expressed in non-neuronal tissues.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.