Thermo Fisher Scientific Phospho-Chk1 (Ser345) Recombinant Rabbit Monoclonal Antibody (Chk1S345-R3F9)
Phospho-Chk1 (Ser345) 항체로 인간, 마우스, 랫트 시료에 반응. 재조합 토끼 단일클론으로 높은 특이성과 재현성 제공. DNA 손상 반응 연구에 적합하며 lot 간 일관성 우수. 비결합형 액상 제품으로 -20°C 보관.
- 판매단위
- pk
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Applications
Flow Cytometry (Flow)
- Tested Dilution: 1–1,000 ng/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | Chk1S345-R3F9 |
| Immunogen | A synthetic phospho-peptide corresponding to residues surrounding Ser345 of human phospho Chk1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2896954 |
Additional Formats
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems by cloning specific antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select optimal candidates for production.
Advantages include:
- Improved specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulations
- Broader immunoreactivity due to larger rabbit immune repertoire
Target Information
CHEK1 (CHK1) is a serine/threonine protein kinase involved in preventing replication when DNA integrity is compromised. It acts as a key mediator in the DNA damage-induced checkpoint network and ensures genomic integrity under genotoxic stress.
Inhibition of CHK1 abrogates G2 or S checkpoint, causing mitotic catastrophe and apoptosis in p53-deficient cancer cells, while normal cells remain arrested in G1. Therefore, CHK1 is an attractive therapeutic target for cancer treatment, especially in p53-deficient tumors.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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