Thermo Fisher Scientific Phospho-c-Cbl (Ser804) Polyclonal Antibody
Phospho-c-Cbl (Ser804) 폴리클로날 항체로, 인간·마우스·랫트 시료에서 인산화된 Ser804 부위의 CBL 단백질을 검출. Western blot 및 IHC(P) 적용 가능. 고순도 정제 및 안정적 PBS/glycerol 저장. 연구용 전용 제품.
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific Phospho-c-Cbl (Ser804) Polyclonal Antibody
Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human CBL (Accession P22681), corresponding to amino acid residues around phosphorylated Ser804 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816960 |
Product Specific Information
Antibody detects endogenous levels of CBL only when phosphorylated at Ser804.
Target Information
Cbl proteins are a family of ubiquitin protein ligases (E3s) that negatively regulate signaling by targeting activated tyrosine kinases for degradation.
Cbl-c is the most recently cloned member of the Cbl proteins and is expressed only in epithelial cells, while other Cbl proteins are ubiquitously expressed.
Cbl-c can ubiquitinate activated EGFR and target it for degradation.
Through interactions with proteins containing SRC homology-2 (SH2) and SH3 domains, CBL proteins modulate downstream cell signaling.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(해당 제품의 항원 이미지 및 구조도는 Thermo Fisher Scientific 공식 자료 참조)
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.