Thermo Fisher Scientific NOTCH1 Monoclonal Antibody (A6)

Applications

Tested Dilution

Publications

Western Blot (WB)

1:100-1:1,000

View 5 publications 5 publications

Immunohistochemistry (IHC)

-

View 7 publications 7 publications

Immunocytochemistry (ICC/IF)

1:20-1:200

-

Flow Cytometry (Flow)

Assay-dependent

View 4 publications 4 publications

Neutralization (Neu)

-

View 3 publications 3 publications

Inhibition Assays (IA)

-

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse

Published species

Human, Mouse, Rat

Host/Isotype

Mouse / IgG2b

Class

Monoclonal

Type

Antibody

Clone

A6

Immunogen

Recombinant protein encoding the ligand binding region of human Notch-1

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.2 mg/mL

Purification

Protein A

Storage buffer

PBS, pH 7.4, with 0.2% BSA

Contains

0.09% sodium azide

Storage conditions

4° C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_10979079

Product Specific Information

MA5-11961 targets Notch-1 in WB, FACS and ICC/IF applications and shows reactivity with Human and mouse samples.

The MA5-11961 immunogen is recombinant protein encoding the ligand binding region of human Notch-1.

Target Information

The notch gene belongs to a family of epidermal growth factor (EGF) like homeotic genes, which encode transmembrane proteins with a variable number of cysteine-rich EGF-like repeats in the extracellular region. Four notch genes have been described in mammals: Notch1, Notch2, Notch3 and Notch4(Int-3), which have been implicated in the differentiation of the nervous system and other structures. The EGF-like proteins Delta and Serrate have been identified as ligands of Notch1. Mature Notch proteins are heterodimeric receptors derived from the cleavage of Notch pre-proteins into an extracellular subunit (NEC) containing multiple EGF-like repeats and a transmembrane subunit including intracellular region (Ntm).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.