Thermo Fisher Scientific UBA52 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:1,000–1:3,000

Immunocytochemistry (ICC/IF)

• Tested Dilution: 1:100–1:500

Product Specifications

Product Specific Information

Antibody detects endogenous levels of total UBA52.

Target Information

Ubiquitin is a highly conserved protein that plays a major role in targeting cellular proteins for degradation by the 26S proteasome. It is synthesized as a precursor protein consisting of either polyubiquitin chains or a single ubiquitin fused to an unrelated protein.
The UBA52 gene encodes a fusion protein composed of ubiquitin at the N-terminus and ribosomal protein S27a at the C-terminus. When expressed in yeast, this protein is post-translationally processed to generate free ubiquitin monomer and ribosomal protein S27a.
Ribosomal protein S27a is a component of the 40S subunit of the ribosome, belongs to the S27AE family, contains C4-type zinc finger domains, and is located in the cytoplasm. Pseudogenes derived from this gene exist in the genome.
Similarly, ribosomal proteins L40 and S30 are synthesized as fusion proteins with ubiquitin or ubiquitin-like proteins.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.