Thermo Fisher Scientific PLS3 Polyclonal Antibody
Human PLS3 단백질에 특이적인 Rabbit Polyclonal 항체로 Western blot 및 IHC(Paraffin)에 적합. 항원 친화 크로마토그래피로 정제되었으며 PBS/glycerol buffer에 보관. 세포 사멸 관련 연구에 활용 가능.
- 카탈로그번호
- PA554206
- 판매단위
- pk
카탈로그
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Thermo Fisher Scientific PLS3 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human PLS3. Recombinant protein control fragment (Product #RP-98847). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2645684 |
Product Specific Information
Immunogen sequence:
PAKFSLVGIG GQDLNDGNQT LTLALVWQLM RRYTLNVLED LGDGQKANDD IIVNWVNRTL SEAGKSTSIQ SFKDKTISSS LAVVDLIDAI QPGCINYDLV KSGNLTEDDK HNNAKYAVSM ARRIGARVYA LPEDLVEVKP GAPHR
Highest antigen sequence identity to the following orthologs:
- Mouse: 94%
- Rat: 90%
Target Information
Phospholipid scramblases (PLS) translocate phospholipids bidirectionally between inner and outer leaflets of the plasma membrane and are implicated in apoptosis. Members of this family, PLS1 and PLS3, are substrates of Protein kinase C (PKC) delta and are phosphorylated by PKC-delta during apoptosis. PKC-delta translocates to mitochondria during apoptosis and phosphorylates PLS3. Overexpression of PLS3 in HEK293 cells enhances apoptosis induced by UV irradiation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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