Thermo Fisher Scientific FCHSD2 Polyclonal Antibody
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Human FCHSD2 단백질에 특이적인 Rabbit Polyclonal Antibody로, IHC(P) 및 ICC/IF에 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, PBS와 글리세롤 버퍼에 보존. 세포 내 수용체 엔도사이토시스 연구에 적합.
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Thermo Fisher Scientific FCHSD2 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:500 |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human FCHSD2 (Product #RP-97343) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2641575 |
Product Specific Information
Immunogen sequence:
LENSSKVVRD YNLQLFLQEN AVFHKPQPFQ FQPCDSDTSR QLESETGTTE EHSLNKEARK WATRVAREHK NIVHQQRVLN DLECHGAAVS EQSRA
Highest antigen sequence identity to the following orthologs:
- Mouse: 97%
- Rat: 98%
Target Information
Adapter protein involved in endocytosis via clathrin-coated pits.
- Contributes to internalization of cell surface receptors (e.g., integrin ITGB1, transferrin receptor).
- Promotes EGFR endocytosis and down-regulation of EGFR signaling in cancer cells.
- Recruited during mid-to-late pit assembly stages for normal pit progression.
- Binds membranes enriched in phosphatidylinositol 3,4-bisphosphate or phosphatidylinositol 3,4,5-trisphosphate.
- Promotes actin polymerization via WAS/WASL interaction and Arp2/3 complex activation.
- Does not promote actin polymerization without membranes.
(Source: UniProt)
For Research Use Only.
Not for use in diagnostic procedures or resale without authorization.
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