Thermo Fisher Scientific FCHSD2 Polyclonal Antibody
FCHSD2 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot 및 IHC에 적합합니다. Human 시료에 반응하며, 항원 친화 크로마토그래피로 정제되었습니다. PBS(glycerol 포함) 용액 형태로 제공되며, 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL | View 2 publications |
| Immunohistochemistry (IHC) | – | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 | – |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human FCHSD2. Recombinant protein control fragment (Product # RP-102835) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2641574 |
Product Specific Information
Immunogen sequence:
VEELSASENG DTPWMREIQI SPSPKPHASL PPLPLYDQPP SSPYPSPDKR SSLYFPRSPS ANEKSLHAES PGFSQASRHT PETSYGKLRP VRA
Highest antigen sequence identity to orthologs:
- Mouse: 92%
- Rat: 89%
Target Information
Adapter protein that plays a role in endocytosis via clathrin-coated pits. Contributes to the internalization of cell surface receptors such as integrin ITGB1 and transferrin receptor. Promotes endocytosis of EGFR in cancer cells, contributing to down-regulation of EGFR signaling. Recruited to clathrin-coated pits during mid-to-late assembly stages, required for normal progression from U-shaped to omega-shaped pits. Binds to membranes enriched in phosphatidylinositol 3,4-bisphosphate or phosphatidylinositol 3,4,5-trisphosphate. When bound to membranes, promotes actin polymerization via interaction with WAS/WASL, leading to Arp2/3 complex activation. Does not promote actin polymerization without membranes.
[UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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