Thermo Fisher Scientific Human TRPV1 Synthetic Peptide

Applications

Control (Ctrl)

• Assay-dependent

Blocking Assay (BLOCK)

• Assay-dependent

Product Specifications

Product Specific Information

This peptide corresponds to 16 amino acids near the carboxy terminus of human TRPV1.
PEP-1540 can be used as a blocking peptide with polyclonal antibody PA5-34498.

Target Information

TRPV1 (Transient Receptor Potential Cation Channel Subfamily V Member 1) is a receptor for capsaicin, the main pungent ingredient in hot chili peppers, and elicits a sensation of burning pain by selectively activating sensory neurons.
TRPV1 is a non-selective cation channel related to TRP family members such as TRPC3 and TRPC6. It is permeable to calcium, magnesium, and monovalent cations of sodium and potassium.
Structurally, TRPV1 contains six transmembrane domains, a P-loop membrane domain, and three ankyrin repeat domains. It is activated by increases in temperature within the noxious range, functioning as a transducer of painful thermal stimuli in vivo.
TRPV1 mediates proton influx and may contribute to intracellular acidosis in nociceptive neurons. Expression appears limited to neurons within sensory ganglia.
Four transcript variants encoding TRPV1 with variations in the 5′ UTR sequence have been described.
Diseases associated with TRPV1 include Irritable Bowel Syndrome (IBS) and Bladder Disease.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.