Thermo Fisher Scientific Phospho-p38 MAPK Pan (Thr180, Tyr182, Thr183, Tyr185) Polyclonal Antibody
인간 및 랫트 시료에 반응하는 폴리클로날 항체로, Thr180, Tyr182, Thr183, Tyr185 부위의 인산화된 p38 MAPK를 검출합니다. Western blot 및 ELISA에 적합하며, 액상 형태로 제공됩니다. 스트레스 및 염증 반응 연구에 유용합니다.
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific Phospho-p38 MAPK Pan (Thr180, Tyr182, Thr183, Tyr185) Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:100–1:500 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic phosphorylated peptide around T180 & Y182 of human MAPK14/MAPK11 (NP_0027423) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.26 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.05% ProClin 300 |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2914933 |
Product Specific Information
- Positive test controls include: C6
- Immunogen sequence: MTGYV
Target Information
The p38 MAPK cascade regulates various cellular responses to stress, inflammation, and other signals. p38 MAPK is relatively inactive in its nonphosphorylated form and becomes rapidly activated by dual phosphorylation of Thr-Gly-Tyr motifs.
There are four isoforms of p38 MAPK that differ in tissue expression and affinity for upstream activators and downstream effectors. Upon exposure to tumor necrosis factor, interleukin-1, heat shock, or other stimuli, MAPK kinase-3 is activated by phosphorylation. Activated MAPK kinase-3/6 then phosphorylates Thr180 and Tyr182 residues in p38 MAPK.
Phospho-p38 MAPK subsequently activates transcription factors such as ATF-2, CHOP-1, and MEF-2 through phosphorylation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.