Thermo Fisher Scientific Phospho-p38 MAPK Pan (Thr180, Tyr182, Thr183, Tyr185) Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

• Positive test controls include: C6
• Immunogen sequence: MTGYV

Target Information

The p38 MAPK cascade regulates various cellular responses to stress, inflammation, and other signals. p38 MAPK is relatively inactive in its nonphosphorylated form and becomes rapidly activated by dual phosphorylation of Thr-Gly-Tyr motifs.
There are four isoforms of p38 MAPK that differ in tissue expression and affinity for upstream activators and downstream effectors. Upon exposure to tumor necrosis factor, interleukin-1, heat shock, or other stimuli, MAPK kinase-3 is activated by phosphorylation. Activated MAPK kinase-3/6 then phosphorylates Thr180 and Tyr182 residues in p38 MAPK.
Phospho-p38 MAPK subsequently activates transcription factors such as ATF-2, CHOP-1, and MEF-2 through phosphorylation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.