Thermo Fisher Scientific CISD2 Monoclonal Antibody (OTI4E8), TrueMAB
CISD2 단백질을 표적으로 하는 Thermo Fisher Scientific의 단클론 항체. Western blot 및 IHC(P)에서 검증됨. 인간 시료 반응성, Mouse IgG1 형식. 액상 형태로 1 mg/mL 농도, -20°C 보관. 연구용으로만 사용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI4E8 |
| Immunogen | Full length human recombinant protein of human CISD2 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Defects in the CISD2 (CDGSH iron sulfur domain 2) gene are a cause of the neurodegenerative disorder Wolfram syndrome 2.
CISD2 is a zinc finger protein that localizes to the endoplasmic reticulum and mitochondria and binds an iron/sulfur cluster.
It interacts with Bcl-2 and can be displaced by the BH3-only protein BIK, contributing to the regulation of BIK-initiated autophagy.
CISD2 deficiency in mice causes mitochondrial breakdown accompanied by autophagic cell death as well as the development of a premature aging phenotype.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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