Thermo Fisher Scientific Phospho-DAXX (Ser671) Polyclonal Antibody
Phospho-DAXX (Ser671) 폴리클로날 항체로 인간 DAXX 단백질의 인산화 부위를 특이적으로 인식합니다. Western blot, IHC, ICC/IF, Flow cytometry, ELISA 등 다양한 응용에 적합하며, Protein A 정제 및 고농도(1 mg/mL) 액상 형태로 제공됩니다. 연구용 전용 제품입니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | Assay-dependent |
| Immunohistochemistry (Frozen) (IHC-F) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| Flow Cytometry (Flow) | 1:20–1:100 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic phosphopeptide derived from human DAXX around the phosphorylation site of Ser671 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
This gene encodes a multifunctional protein that resides in multiple locations in the nucleus and cytoplasm. It interacts with proteins such as apoptosis antigen Fas, centromere protein C, and transcription factor E26 oncogene homolog 1. In the nucleus, it acts as a potent transcription repressor binding to sumoylated transcription factors. Its repression can be relieved by sequestration into promyelocytic leukemia nuclear bodies or nucleoli. The protein also associates with centromeres in G2 phase and may regulate apoptosis in the cytoplasm. Its localization and function are modulated by post-translational modifications including sumoylation, phosphorylation, and polyubiquitination. Alternative splicing results in multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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