Thermo Fisher Scientific HLA-DQB2 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:3,000
• Publications: N/A

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:100–1:1,000
• Publications: N/A

Product Specifications

Product Specific Information

• Recommended positive controls: K562
• Predicted reactivity: Human (99%)
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

HLA-DQB2 belongs to the family of HLA class II beta chain paralogs. Class II molecules are heterodimers consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. They play a central role in the immune system by presenting peptides derived from extracellular proteins.
Class II molecules are expressed in antigen-presenting cells (APC: B lymphocytes, dendritic cells, macrophages). Polymorphisms in the alpha and beta chains specify peptide binding specificity, and typing for these polymorphisms is routinely done for bone marrow transplantation.
However, HLA-DQB2 is not routinely typed, as it is not thought to affect transplantation. There is conflicting evidence in the literature and public sequence databases regarding the protein-coding capacity of HLA-DQB2.
HLA and MHC antibodies play a significant role in Immunopeptidomics, facilitating the identification and characterization of neoantigens through high-performance liquid chromatography coupled to tandem mass spectrometry.

⚠ WARNING: This product can expose you to chemicals including mercury, known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.