Thermo Fisher Scientific Phospho-PDHA1 (Ser293) Recombinant Rabbit Monoclonal Antibody (6E3J0)
Phospho-PDHA1 (Ser293) 특이적 재조합 토끼 단클론 항체로 Western blot, ELISA, IP에 적합. 인간, 마우스, 랫트 반응성. 고순도 친화 크로마토그래피 정제, 액상 형태로 안정적 보관 가능. 연구용 전용 제품.
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Thermo Fisher Scientific Phospho-PDHA1 (Ser293) Recombinant Rabbit Monoclonal Antibody (6E3J0)
Applications and Tested Dilution
- Western Blot (WB): 1:2,000–1:20,000
- ELISA: 1 µg/mL
- Immunoprecipitation (IP): 0.5 µg–4 µg antibody for 200 µg–400 µg extracts
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 6E3J0 |
| Immunogen | Synthetic phosphorylated peptide around S293 of human PDHA1 (P08559) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.58 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol, 0.05% BSA |
| Contains | 0.05% ProClin 300 |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2849764 |
Product Specific Information
Immunogen sequence: GHSMSD
Target Information
The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the conversion of pyruvate to acetyl-CoA and CO₂, providing the primary link between glycolysis and the tricarboxylic acid (TCA) cycle.
The PDH complex consists of multiple copies of three enzymatic components:
- Pyruvate dehydrogenase (E1)
- Dihydrolipoamide acetyltransferase (E2)
- Lipoamide dehydrogenase (E3)
The E1 enzyme is a heterotetramer of two alpha and two beta subunits. The PDHA1 gene encodes the E1 alpha 1 subunit containing the E1 active site and is essential for PDH complex function. Mutations in this gene are associated with pyruvate dehydrogenase E1-alpha deficiency and X-linked Leigh syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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