Thermo Fisher Scientific Phospho-P53 (Ser20) Polyclonal Antibody

Thermo Fisher Scientific Phospho-P53 (Ser20) Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Target Information

The tumor suppressor protein p53 is a sequence-specific transcription factor activated by cellular stress. It mediates cell cycle arrest or apoptosis in response to DNA damage or nutrient deprivation. p53 upregulates genes such as p21waf1 involved in G1 or G2/M arrest. Structurally, p53 contains an N-terminal transactivation domain, a central DNA-binding domain, an oligomerization domain, and a C-terminal regulatory domain.

Phosphorylation at Ser15 is crucial for activation and stabilization, while Ser392 phosphorylation is associated with tumor formation. p53 plays roles in preventing proliferation of damaged cells, aging, oxidative stress response, and memory-related processes. Mutations in the TP53 gene are common in human cancers and lead to loss of tumor suppressor activity. Germline mutations can cause cancer-prone syndromes such as Li-Fraumeni.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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