Thermo Fisher Scientific TRIM56 Monoclonal Antibody (OTI5A1), TrueMAB
TRIM56 단백질을 인식하는 마우스 단클론 항체로 Western blot과 IHC(P) 실험에 적합. 인간 시료에 반응하며, 고순도의 액상 항체 형태로 제공. E3 유비퀴틴 리가아제 TRIM56 연구 및 항바이러스 면역 기전 연구에 활용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI5A1 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 311–554 of human TRIM56 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
E3 ubiquitin-protein ligase that plays a key role in innate antiviral immunity (PubMed:21289118).
In response to pathogen- and host-derived double-stranded DNA (dsDNA), TRIM56 targets STING1 to Lys-63-linked ubiquitination, promoting its homodimerization required for type I interferon IFN-beta production.
Independently of its E3 ubiquitin ligase activity, TRIM56 acts as a positive regulator of TLR3 signaling.
It enhances extracellular double-stranded RNA (dsRNA)-induced expression of IFNB1 and interferon-stimulated genes (ISG15, IFIT1/ISG56, CXCL10, OASL, CCL5/RANTES), and promotes antiviral state establishment following infection by hepatitis C virus (PubMed:22948160).
[UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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