Thermo Fisher Scientific GCR2/SGT1 Polyclonal Antibody
Thermo Fisher Scientific의 GCR2/SGT1 Polyclonal Antibody는 인간 GCR2 억제 단백질 영역(614–644)을 인식하는 Rabbit IgG 항체입니다. Western blot과 Immunoprecipitation에 적합하며, 액상 형태로 4°C에서 보관합니다. 연구용으로만 사용 가능합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000–1:10,000
- Publications: [References not provided]
Immunoprecipitation (IP)
- Tested Dilution: 2–5 µg/mg lysate
- Publications: [References not provided]
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 614 and 644 of Human Suppressor of GCR2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.20 mg/mL |
| Storage conditions | 4°C |
| Shipping conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
Target Information
Regulator of p53/TP53 stability and function. Inhibits MDM2-mediated degradation of p53/TP53 possibly by cooperating in part with TXNIP (PubMed:16849563, PubMed:23880345).
May be involved in transcriptional regulation. In vitro has intrinsic transactivation activity enhanced by EP300.
May be a transcriptional activator required for the expression of glycolytic genes (PubMed:19919181, PubMed:9928932).
Involved in regulation of cell cycle progression. Proposed to disrupt Rb-E2F binding leading to transcriptional activation of E2F proteins (PubMed:19640839).
The cell cycle-regulating function may depend on its RUVBL1-mediated association with the R2TP complex (PubMed:26711270).
May play a role in regulation of pre-mRNA splicing (PubMed:24722212).
[UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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