Thermo Fisher Scientific Phospho-Neuropilin-1 (Tyr297) Polyclonal Antibody
Phospho-Neuropilin-1 (Tyr297) 폴리클로날 항체로 인간, 마우스, 랫트 시료에 반응. Western blot 및 IHC(P) 검증 완료. 항원 친화 크로마토그래피로 정제된 고품질 항체. VEGF 유도 혈관신생 연구 및 신경세포 발달 연구에 적합.
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Thermo Fisher Scientific Phospho-Neuropilin-1 (Tyr297) Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.1–1 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 2–10 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide SSQ-Y*-STNWSA corresponding to phosphorylation site Tyr297 of Neuropilin-1 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 25 mM Tris with proprietary stabilizer |
| Contains | 0.01% sodium azide |
| Storage Conditions | Store at 4°C short term; for long term store at -20°C, avoiding freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive control: Kidney tissue
- Cellular location: Secreted and membrane
Target Information
Neuropilin 1 is a 923-amino-acid membrane-bound coreceptor belonging to the neuropilin family. It contains two CUB domains, two F5/8 type C domains, and a MAM domain. Neuropilin 1 forms a heterodimer with Neuropilin 2 (NRP2) and binds to plexin (PLXNB1) to form semaphorin receptors.
It is highly expressed in the nervous system and plays roles in cardiovascular development, angiogenesis, axon guidance, neuronal circuit formation, cell survival, neuronal migration, and organogenesis.
Neuropilin 1 functions as a receptor for both semaphorins and VEGF, regulating VEGF-induced angiogenesis. It may also be involved in advanced prostate carcinoma and breast cancer progression.
Usage Note
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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