Thermo Fisher Scientific Thymidine Phosphorylase/PD-ECGF Recombinant Rabbit Monoclonal Antibody (TYMP, 2890R)

Applications

Western Blot (WB)

• Tested Dilution: 2–4 µg/mL

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1–2 µg/mL

Product Specifications

Product Specific Information

• Immunohistochemistry (PFA fixed): Incubate antibody for 30 min at room temperature.
• Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C, followed by cooling at room temperature for 20 minutes.

Target Information

Thymidine Phosphorylase (TP), also known as platelet-derived endothelial cell growth factor (PD-ECGF) or gliostatin, catalyzes the reversible phosphorolytic cleavage of thymidine and deoxyuridine to their corresponding bases and 2-deoxyribose-1-phosphate in the presence of inorganic orthophosphate.
It is chemotactic and mitogenic for endothelial cells and acts as a non-heparin-binding angiogenic factor present in platelets.
Additionally, it plays a role in the conversion of fluoropyrimidines, cytotoxic agents used in cancer treatment, into active cytotoxic metabolites.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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