Thermo Fisher Scientific NALP4 Polyclonal Antibody
Thermo Fisher Scientific의 NALP4 Polyclonal Antibody는 Human, Mouse, Rat에 반응하며 Rabbit IgG 기반의 액상 항체입니다. 다양한 IHC, ICC/IF, ELISA 실험에 적합하며, NF-kappa-B 신호 조절 연구에 활용됩니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human NALP4, amino acids 351–450 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
NALP proteins include the apoptosis regulator APAF1 and mammalian NOD-LRR proteins, which are thought to be involved in inflammation and reproduction.
NALP4 (PYRIN-containing APAF1-like protein 4) possesses a C-terminal leucine-rich repeat (LRR) region, an N-terminal Pyrin domain (PYD), a NACHT domain, and a NACHT-associated domain.
In transfected 293 cells, NALP4 suppressed NF-kappa-B induction by TNF-α and IL-1-β, indicating that NALP4 acts at a convergence point in these signaling pathways. It also inhibited NF-kappa-B activation triggered by overexpression of TRAF2, TRAF6, RIP, IRAK2, IKK-α, and IKK-β, suggesting a critical role in modulating NF-kappa-B activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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