Thermo Fisher Scientific DISC1 Polyclonal Antibody
DISC1 단백질을 인식하는 토끼 폴리클로날 항체로, 인간·생쥐·랫드 시료에 반응합니다. IHC(P), IHC(F), ICC/IF에 적합하며 항원 친화 크로마토그래피로 정제되었습니다. 뇌 조직에서 양성 대조군으로 사용 가능하며, 신경세포 연구에 유용합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 2.5–5 µg/mL |
| Immunohistochemistry (Frozen) (IHC (F)) | Assay-Dependent |
| Immunocytochemistry (ICC/IF) | 1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide made to an internal region (within residues 400–500) of the rat DISC1 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | TBS |
| Contains | 0.05% sodium azide |
| Storage Conditions | −20 °C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2091162 |
Product Specific Information
- The theoretical molecular weight of DISC1 is approximately 90 kDa.
- Due to alternative splicing, DISC1 may also appear at ~75 kDa and ~100 kDa.
- Suggested positive control: human brain sections (neurons and glia).
Target Information
DISC1 (Disrupted in Schizophrenia 1) is a multifunctional protein that interacts with centrosomal and cytoskeletal proteins, playing a crucial role in neuronal functions such as migration, neurite architecture, and intracellular transport. It is expressed in brain regions including the hippocampus, lateral septum, amygdala, cerebral cortex, cerebellum, and paraventricular hypothalamus.
Loss of DISC1 function is associated with altered brain structural organization and linked to schizophrenia due to chromosomal translocations. DISC1 interacts with proteins such as MIPT3, MAP1A, NUDEL, α-actinin 2, β4-spectrin, ATF-4, and ATF-5, suggesting roles in intracellular transport, neurite architecture, and neuronal migration.
Reduced DISC1 expression leads to abnormal neuronal development, indicating its involvement in dendritic growth and synapse formation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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