Thermo Fisher Scientific CD45RB (B-Cell Marker) Monoclonal Antibody (BRA-11 (BRA-11G))
인간 CD45RB 항원을 인식하는 Mouse IgG1 모노클로날 항체로, B세포 마커로 사용됩니다. Western blot, IHC, ICC, Flow cytometry 등 다양한 응용에 적합하며, Protein A/G로 정제된 액상 형태입니다. 연구용으로만 사용됩니다.
- 카탈로그번호
- 5788-MSM6-Px (2개 옵션)
- 판매단위
- pk
카탈로그
2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific CD45RB (B-Cell Marker) Monoclonal Antibody (BRA-11 (BRA-11G))
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
| Immunocytochemistry (ICC/IF) | 1–2 µg/mL |
| Flow Cytometry (Flow) | 1–2 µg/10^6 cells |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | BRA-11 (BRA-11G) |
| Immunogen | Non-T, non-B CALLA positive ALL cell line REH (Leucocyte Workshop IV and V) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Additional Formats
- CF 488
- PE
- Custom conjugation available upon request
Product Specific Information
Does not react with Rat or Rhesus Monkey.
Target Information
CD45RB is a receptor-type protein tyrosine phosphatase and a CD45 glycoprotein isoform. CD45 plays a critical role in lymphocyte development and antigen signaling, regulating Src-family kinases and promoting cell survival through integrin-mediated signaling pathways. It is also involved in DNA fragmentation during apoptosis.
CD45 isoforms differ in extracellular domains but share identical transmembrane and cytoplasmic domains. Their expression varies by cell type and physiological state. CD45RB is expressed in microglia and inflammatory cells and is essential for immunoreceptor signaling and hematopoietic lineage cell function, excluding mature red cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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