Thermo Fisher Scientific CD11b Chimeric Recombinant Rat Monoclonal Antibody (5C6 (recombinant version))
CD11b 단백질을 특이적으로 인식하는 재조합 랫트 단클론 항체로, 인간 및 마우스 시료에 반응합니다. IHC(F), ICC/IF, Flow Cytometry에 사용 가능하며, Protein A로 정제된 액상 형태입니다. 단기 4°C, 장기 -20°C 보관 권장.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Frozen) (IHC (F)) | Assay-dependent |
| Immunocytochemistry (ICC/IF) | Assay-dependent |
| Flow Cytometry (Flow) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rat / IgG2b, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 5C6 (recombinant version) |
| Immunogen | Fusion of spleen cells from AO rats immunised with Thioglycollate-elicted murine peritoneal macrophages (TPM) and the Y3 rat myeloma line. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
Product Specific Information
This antibody specifically recognizes CD11b, also known as the integrin alpha M chain (MAC-1), a differentiation antigen expressed by granulocytes, monocytes, NK cells, and tissue macrophages.
Target Information
CD11b (integrin alpha-M, ITGAM, integrin alpha-X, ITGAX) is a 165 kDa adhesion molecule that associates non-covalently with integrin beta-2 (CD18). The CD11b/CD18 heterodimeric complex, also known as integrin alpha-M beta-2, Mac-1, and CR3 (complement receptor 3), is expressed on monocytes/macrophages, granulocytes, activated lymphocytes, a subset of NK cells, dendritic cells, and microglia.
CD11b/CD18 functions as the receptor for ICAM-1 (CD54), ICAM-2 (CD102), ICAM-4 (CD242), CD14, CD50, CD23, heparin, iC3b, fibrinogen, and Factor X. These interactions are critical for cell-cell and cell-matrix adhesion.
CD11b expression:
- 8% of spleen cells
- 44% of bone marrow cells
- <1% of thymocytes
It is commonly used as a microglial marker in nervous tissue. Expression increases during monocyte maturation and varies among tissue macrophages. Peritoneal macrophages express higher CD11b levels than splenic macrophages.
Diseases associated with CD11b dysfunction include systemic lupus erythematosus and ITGAM-related susceptibility to systemic lupus erythematosus.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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