Thermo Fisher Scientific PRMT10 Polyclonal Antibody
PRMT10 단백질을 인식하는 Thermo Fisher Scientific의 토끼 다클론 항체로, Western blot과 Immunoprecipitation에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, 1 mg/mL 농도의 액상 형태로 제공됩니다. 인체 시료 반응성이 확인된 연구용 시약입니다.
- 카탈로그번호
- A304189Ax (2개 옵션)
- 판매단위
- pk
카탈로그
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Applications
Western Blot (WB)
- Tested Dilution: Assay-dependent
Immunoprecipitation (IP)
- Tested Dilution: 2–10 µg/mg lysate
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 1 to 50 of Human Protein Arginine Methyltransferase 10 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | Phosphate/Tris citrate, pH 7–8 |
| Contains | 0.09% sodium azide |
| Storage conditions | 4°C |
| Shipping conditions | Wet ice |
Product Specific Information
- The recommended shelf life for this product is 1 year from the date of receipt.
Target Information
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as DTL/CDT2, BCL6, and PRDM1/BLIMP1.
The SCF(FBXO11) complex mediates ubiquitination and degradation of BCL6, thereby playing a role in the germinal center B-cells terminal differentiation toward memory B-cells and plasma cells.
It also mediates ubiquitination and degradation of DTL, an important step for the regulation of TGF-beta signaling, cell migration, and the timing of cell-cycle progression and exit.
Binds to and neddylates phosphorylated p53/TP53, inhibiting its transcriptional activity. SCF(FBXO11) does not seem to direct ubiquitination of p53/TP53.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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