Thermo Fisher Scientific MSL2 Monoclonal Antibody (OTI3G5), TrueMAB

Applications

Tested Dilution

Publications

Western Blot (WB)

1:2,000

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

OTI3G5

Immunogen

Full length human recombinant protein of human MSL2 produced in E.coli. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:MSL2,uniProtId:Q9HCI7-1,ncbiNodeId:9606,antigenRange:1-577,antigenLength:577,antigenImageFileName:TA811223_MSL2_Q9HCI7-1_House_mouse.svg,antigenImageFileNamePDP:TA811223_MSL2_Q9HCI7-1_House_mouse_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS with 1% BSA, 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

Component of histone acetyltransferase complex responsible for the majority of histone H4 acetylation at lysine 16 which is implicated in the formation of higher-order chromatin structure. Acts as an E3 ubiquitin ligase that promotes monoubiquitination of histone H2B at Lys-35 (H2BK34Ub), but not that of H2A. This activity is greatly enhanced by heterodimerization with MSL1. H2B ubiquitination in turn stimulates histone H3 methylation at Lys-4 (H3K4me) and Lys-79 (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1. [UniProt]

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.