Thermo Fisher Scientific CD83 Polyclonal Antibody
CD83 단백질을 인식하는 Thermo Fisher Scientific의 폴리클로날 항체로, WB, IHC, ELISA 등 다양한 응용에 사용 가능. 사람, 마우스, 랫트 반응성. 단백질 A로 정제된 액상 항체로 -20°C 보관. 연구용으로만 사용.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | Assay-dependent |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic peptide derived from mouse CD83, amino acids 121–196 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
CD83 is a 40–45 kDa cell surface glycoprotein expressed by peripheral blood dendritic cells. Peripheral lymphocytes can express low levels of CD83 after stimulation with agents such as Con A or PHA. In immunohistology, CD83 is strongly expressed by interfollicular interdigitating reticulum cells and weakly by cells within germinal centers. It is also expressed by Langerhans cells in the skin.
The CD83 antigen is a 186-amino-acid single-chain glycoprotein belonging to the immunoglobulin superfamily, composed of an extracellular V-type Ig-like domain, a transmembrane region, and a short cytoplasmic tail. Extensive post-translational glycosylation results in a molecular weight approximately twice that of the predicted core protein. CD83⁺ cells exhibit a unique immunophenotype distinct from T, B, NK, or myelomonocytic cells, coexpressing high levels of MHC class II molecules and various lineage markers including CD2, CD5, CD40, CD78, CD13, CD33, and CD36. CD83 dysfunction has been associated with diseases such as plague and Rift Valley fever.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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