Thermo Fisher Scientific NAB2 Monoclonal Antibody (OTI5D7), TrueMAB
NAB2 단백질을 인식하는 Mouse monoclonal antibody (Clone OTI5D7). Western blot과 IHC(P)에서 검증됨. 동결건조 형태로 제공되며 PBS buffer에 8% trehalose 포함. 인간 단백질 특이적 반응, 연구용으로만 사용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI5D7 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 178–442 of human NAB2 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL of distilled water to reach a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
Transcriptional control is partly regulated by interactions between DNA-bound transcription factors such as Egr-1/NGFI-A and coregulatory proteins like NAB (NGFI-A-binding proteins).
The NAB protein family, including NAB1 and NAB2, act as corepressors of Egr-1/NGFI-A. Both contain conserved domains:
- NCD1 (amino-terminal): required for binding NGFI-A
- NCD2 (carboxy-terminal): responsible for repressor function
NAB2 is primarily localized in the nucleus and may regulate NGFI-A activity, cell division, differentiation, and apoptosis.
It has a predicted molecular mass of 56 kDa and is located on chromosome 12q13.3–14.1, a region associated with several solid tumors, lipomas, and liposarcomas.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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