Thermo Fisher Scientific NCOA4 Monoclonal Antibody (OTI2F5), TrueMAB
인간 NCOA4 단백질(aa 280-553)을 면역원으로 제작된 Mouse monoclonal antibody. Western blot에 1:2,000 희석으로 검증됨. Affinity chromatography로 정제되었으며 PBS/BSA/glycerol buffer에 보관. -20°C에서 보관, 동결-해동 반복 회피.
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Applications
- Western Blot (WB): 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2F5 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 280–553 of human NCOA4 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | −20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Target Information
Androgen receptor (AR) coactivator ARA70, also designated NCOA4, RFG, and ELE1, is a putative co-activator that specifically enhances the activity of the androgen receptor. In human thyroid carcinomas, the Ret proto-oncogene fuses to ARA70 to form Ret/PTC3 by intrachromosomal inversion. ARA70 is expressed as two isoforms, ARA70a and ARA70b. The shorter variant ARA70b results from an internal 985-bp deletion. ARA70a is widely expressed, with highest expression in testis and adipose tissues, whereas ARA70b is solely expressed in the testis. ARA70a can function as a ligand-enhanced co-activator of PPARγ in adipocytes. ARA70 may be involved in prostate and ovarian carcinogenesis and may serve as a key mediator of estrogen-androgen synergism.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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