Thermo Fisher Scientific PALB2 Monoclonal Antibody (OTI1E7), TrueMAB
PALB2 단백질을 인식하는 Mouse IgG1 단일클론 항체로, Western blot에 최적화되어 있습니다. BRCA1/BRCA2 관련 DNA 손상 복구 연구에 활용됩니다. 1 mg/mL 농도의 액상 형태이며, -20°C에서 보관합니다.
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Applications
- Western Blot (WB)
Tested Dilution: 1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1E7 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 1–287 of human PALB2 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The breast cancer early onset proteins BRCA1 and BRCA2 are central to the repair of DNA damage by homologous recombination and are strongly associated with inherited breast and ovarian cancer.
The protein PALB2 is required for the localization of BRCA2 to sites of DNA damage and, like BRCA1 and BRCA2, is a breast cancer susceptibility gene.
PALB2 functions through direct binding to BRCA1, organizing BRCA2 and the recombinase RAD51 at DNA damage sites.
Analysis of the BRCA1–PALB2–BRCA2–RAD51 network may help predict tumor responsiveness to therapeutic treatments.
At least four isoforms of PALB2 are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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