Thermo Fisher Scientific MMS19 Polyclonal Antibody
Human MMS19 단백질을 인식하는 Rabbit Polyclonal 항체로, WB, IHC(P), ICC/IF에 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, PBS 버퍼(40% 글리세롤 포함)에 보관. DNA 대사 및 염색체 분리에 관여하는 MMS19 단백질 연구에 적합.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human MMS19. Recombinant protein control fragment (Product #RP-98499) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2644017 |
Product Specific Information
Immunogen sequence:
IVPLFLDGNV SFLPENSFPS RFQPFQDGSS GQRRLIALLM AFVCSLPRNV EIPQLNQLMR ELLELSCCHS CPFSSTAAAK CFAGLLNKHP A
Highest antigen sequence identity to the following orthologs:
- Mouse: 87%
- Rat: 84%
Target Information
MMS19 is a key component of the cytosolic iron-sulfur protein assembly (CIA) complex, which mediates the incorporation of iron-sulfur clusters into apoproteins involved in DNA metabolism and genomic integrity. Within the CIA complex, MMS19 functions as an adapter between early-acting CIA components and target iron-sulfur proteins such as ERCC2/XPD, FANCJ, and RTEL1, playing a critical role in nucleotide excision repair (NER) and RNA polymerase II (POL II) transcription.
As part of the mitotic spindle-associated MMXD complex, MMS19 contributes to chromosome segregation, likely by facilitating iron-sulfur cluster assembly into ERCC2/XPD. It also acts indirectly as a transcriptional coactivator of estrogen receptor (ER) through its role in iron-sulfur insertion into TFIIH machinery components.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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