Thermo Scientific™

CellSensor™ NFkB-bla ME-180 Cell Line

The CellSensor™ NFκB-bla ME-180 cell line contains a beta-lactamase reporter gene under control of the Nuclear Factor Kappa B (NFκB)자세히 알아보기

The CellSensor™ NFκB-bla ME-180 cell line contains a beta-lactamase reporter gene under control of the Nuclear Factor Kappa B (NFκB) response element stably integrated into ME-180 cells. The cell line was created through fluorescence activated cell sorting (FACS) of cells responsive to stimulation of the NFκB pathway with tumor necrosis factor alpha (TNFα). The cell line was validated for DMSO tolerance, incubation time with stimulant, and substrate loading conditions. The CellSensor™ NFκB-bla ME-180 cell line responds to agonist treatment as expected from literature and can be adapted for high-throughput screening for agonists or antagonists of the NFκB pathway with compound libraries. Candidate drugs can also be tested for dose response against this cell line. Academic and non-profit customers, please inquire for special pricing.

사양

어세이 입력Cell-based beta lactamase reporter gene

셀 상태Dividing Cells

제품라인CellSensor™

수량1 Vial

타겟 입력TNF alpha, NIK, TLR, I kappa B, IRAK, IKK, NF-kappa B pathway

유형Cell Line

세포주ME-180

System TypeCellSensor™

Druggable TargetSignaling Pathway

Unit SizeEach