Thermo Fisher Scientific ALK Monoclonal Antibody (OTI5F4), TrueMAB

Applications

• Western Blot (WB): Tested dilution 1:2,000

Product Specifications

Product Specific Information

For reconstitution, add 100 µL of distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

Anaplastic Lymphoma Receptor Tyrosine Kinase (ALK) belongs to the insulin receptor superfamily and plays a crucial role in brain development.
Mutations, rearrangements, and amplifications of the ALK gene are associated with various tumors, including anaplastic large cell lymphoma, neuroblastoma, and non-small cell lung cancer.
Chromosomal rearrangements often result in the NPM-ALK fusion gene, which produces an oncogenic protein.
ALK is a receptor protein-tyrosine kinase with transmembrane and extracellular domains, showing high sequence similarity to LTK. It is essential for neuronal development and signaling in the nervous system.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.