Thermo Fisher Scientific c-Cbl Polyclonal Antibody
Thermo Fisher Scientific의 c-Cbl Polyclonal Antibody는 인간 단백질에 반응하는 토끼 유래 IgG 항체입니다. Western blot 및 Immunoprecipitation에 사용 가능하며, 항원 친화 크로마토그래피로 정제되었습니다. 연구용으로만 사용되며, 4°C에서 보관합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000–1:10,000
Immunoprecipitation (IP)
- Tested Dilution: 2–5 µg/mg lysate
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 675 and 725 of human Casitas B-lineage lymphoma proto-oncogene |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.20 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | TBS, pH 7.0–8.0, with 0.1% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt.
Target Information
Cbl proteins are a family of ubiquitin protein ligases (E3s) that negatively regulate signaling by targeting activated tyrosine kinases for degradation.
Cbl-c is the most recently cloned member of the Cbl proteins and is expressed only in epithelial cells, whereas other Cbl proteins are ubiquitously expressed.
Cbl-c, like other mammalian Cbl proteins, can ubiquitinate the activated EGFR and target it for degradation.
Through interactions with proteins containing SRC homology-2 (SH2) and SH3 domains, CBL proteins modulate downstream cell signaling.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(해당 항원의 구조 이미지: A302-338A_c-Cbl_P22681-1_Rabbit.svg / A302-338A_c-Cbl_P22681-1_Rabbit_PDP.jpeg)
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