Thermo Fisher Scientific STAM 1, 2 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:300-1:2,000

-

Immunohistochemistry (IHC)

1:300-1:2,000

-

Miscellaneous PubMed (Misc)

-

View 2 publications 2 publications

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Not Applicable

Host/Isotype

Sheep / Ig

Class

Polyclonal

Type

Antibody

Immunogen

A synthetic peptide from aa region 300-360 of human STAM 1, 2 (STAM-1, STAM-2) conjugated to an immunogenic carrier protein was used as the antigen if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:STAM1/STAM2,uniProtId:O75886-1,ncbiNodeId:9606,antigenRange:300-360,antigenLength:525,antigenImageFileName:OSS00134W-100UL_STAM1STAM2_O75886-1_Sheep.svg,antigenImageFileNamePDP:OSS00134W-100UL_STAM1STAM2_O75886-1_Sheep_PDP.jpeg,sortOrder:1},{targetFamily:STAM1/STAM2,uniProtId:Q92783-1,ncbiNodeId:9606,antigenRange:300-360,antigenLength:540,antigenImageFileName:OSS00134W-100UL_STAM1STAM2_Q92783-1_Sheep.svg,antigenImageFileNamePDP:OSS00134W-100UL_STAM1STAM2_Q92783-1_Sheep_PDP.jpeg,sortOrder:2}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

Conc. Not Determined

Storage buffer

whole serum

Contains

no preservative

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability.

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.

The peptide is homologous in many species including rat, mouse, zebra fish and xenopus.

Specificity of this antibody: STAM1 and 2.

Target Information

STAM1 is involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and c-myc induction. May also play a role in endocytic trafficking as well as in T-cell development. Subunit: Heterodimer. Composed of STAM1 and HGS/HRS. Also interacts directly with STAMBP/AMSH. Tissue Specificity: Ubiquitously expressed. STAM2 is involved in intracellular signal transduction mediated by cytokines and growth factors. Probably acts via its association with ubiquitinated cargo proteins on the early endosome participates in their sorting for trafficking to the lysosome. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and c-myc induction. May also play a in T-cell development. Subunit: Heterodimer or heterotrimer. At least composed of STAM2 and HGS/Hrs. EPS15 can be part of the complex. Interacts directly with STAMBP/AMSH, JAK2 and JAK3. Also interacts with ubiquitinated proteins and the deubiquitinating enzyme USP8/UBPY. Interacts directly with CBX5 via the PxVxL motif. Interacts with VPS37C. Tissue Specificity: Ubiquitously expressed.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.