Thermo Fisher Scientific DKC1 Polyclonal Antibody
DKC1 단백질을 인식하는 Rabbit Polyclonal 항체로, Human, Mouse, Rat 시료에 반응합니다. Western blot, IHC, ICC/IF에 사용 가능하며, 고순도 Affinity chromatography로 정제되었습니다. PBS/glycerol buffer에 보관되며 -20°C에서 안정적으로 저장됩니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human DKC1 (Accession O60832), corresponding to amino acid residues R183–L233 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2851904 |
Product Specific Information
Antibody detects endogenous levels of total DKC1.
Target Information
The DKC1 gene encodes a member of the H/ACA snoRNPs gene family, which plays a critical role in rRNA processing and modification. H/ACA snoRNPs include NOLA1, NOLA2, and NOLA3 proteins. The DKC1 protein and NOLA proteins localize to nucleoli and coiled bodies within the nucleus. Deficiency of any of these proteins impairs 18S rRNA production and pseudouridylation. These proteins are also components of the telomerase complex.
The DKC1 gene is homologous to Saccharomyces cerevisiae Cbf5p and Drosophila melanogaster Nop60B proteins. Mutations in DKC1 cause X-linked dyskeratosis congenita and Hoyeraal-Hreidarsson syndrome, disorders characterized by abnormal skin pigmentation, mucosal leukoplakia, nail dystrophy, and bone marrow failure. Two transcript variants encoding different isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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