Thermo Fisher Scientific Amphiregulin Polyclonal Antibody
Thermo Fisher Scientific의 Amphiregulin Polyclonal Antibody는 인간, 마우스, 랫트에서 반응하며 WB 및 IHC(P) 분석에 적합합니다. Rabbit IgG 폴리클로날 항체로, 고순도 친화 크로마토그래피 정제 제품입니다. PBS/glycerol 버퍼에 보관하며 -20°C에서 안정적입니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
- Publications: [참조 없음]
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
- Publications: [참조 없음]
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human AREG (Accession P15514), corresponding to amino acid residues G60–P110 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2851903 |
Product Specific Information
Antibody detects endogenous levels of total AREG.
Target Information
Amphiregulin (AR) binds to EGF-Receptor (EGFR) with lower affinity than EGF. The mature secreted form AR is an 84-amino acid glycosylated polypeptide growth regulator, generated by proteolytic processing of a 252-amino acid transmembrane precursor.
Seven distinct polypeptide ligands can bind to the extracellular domain of EGFR — EGF, TGFα, AR, HB-EGF, cripto-1, epiregulin, and betacellulin.
All these growth factors contain a characteristic EGF-like domain defined by six evenly spaced cysteine residues forming three loops via disulfide bonds.
AR protein has been localized by immunohistochemistry to the epithelium of the colon, stomach, pancreas, breast, and placenta, and is reportedly overexpressed in human cancers of these tissues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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